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- Role of Oxygen Debt in the Development of Organ Failure Sepsis, and Death in High-Risk Surgical Patients (7)

Role of Oxygen Debt in the Development of Organ Failure Sepsis, and Death in High-Risk Surgical Patients (7)Statistical Evaluation
Statistical analyses of the sequential patterns of variables before, during, and after operation were performed using the analysis of variance (ANOVA) and the Newman-Keuls test. The x2 and Student t tests were used to compare the number of organ failures in survivors vs nonsurvivors and in control vs protocol groups and the times of onset of organ failure. Values for p less than 0.05 were considered significant.
Results
Preoperative Baseline Hemodynamics and Oxygen Transport
Table 2 summarizes preoperative baseline hemodynamics, arterial oxygen tension (Pa02), Do2, and Vo2 values of those who died during their hospitalization, survivors with organ failure or complications, and survivors without organ failure or complications. There was considerable similarity among these baseline control values of the groups, but the nonsurvivors had slightly higher wedge pressures and lower Do2 than the other two groups, while survivors without either organ failure or complications had slightly higher Cl and Do2 than the other two groups; however, these preoperative values were within normal limits and were not statistically significant by ANOVA or by Student t test.

Table 2—Preoperative Values of Nonsurvivors, Survivors with Complications, and Survivors Without Complications

Data Survivors without Organ Failure or Complications Survivors with Organ Failure or Complications Nonsurvivors
MAP, mm Hg 98± 1 97 ±3 97 ±3
Heart rate, beats per min 92 ±4 83±4 100 ±4
PAWP, mm Hg 9.8± 1.4 8.8± 1.2 12.3 ±1.3
Cl, L/min/m2 4.0±0.2 3.5±0.2 3.5±0.2
Hematocrit, percent 34±0.4 33± 1 32 ±18
Pa02, mm Hg 130 ±6 112 ± 11 128 ±12
Do2, ml/min/m2 586 ±29 503 ±28 485 ±27
Vo2, ml/min/ml2 122 ±3 114 ±5 123 ±5
August 14, 2013 Oxygen
Tags: anesthesia cardiac output organ failure oxygen