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- Role of Oxygen Debt in the Development of Organ Failure Sepsis, and Death in High-Risk Surgical Patients (2)

Subsequently, increased cardiac output and Vo2 values were reported in patients with various surgical illnesses,’ but these studies primarily involved Vo2 measurements in the postoperative period after the hemodynamic crisis. When temporal patterns of Vo2 were observed throughout the perioperative course by frequent serial Vo2 measurements, an early reduction in Vo2 was observed at or prior to the initial hypotensive crisis and was followed by compensatory increases in cardiac output and Vo2.n 15 These increases were greater in the survivors. Increased Vo2 was also reported by other investigators in septic, traumatic, and postoperative patients, especially in the patients given fluid therapy. Moreover, prospective trials have shown improved survival when Vo2 was increased by fluids and inotropic therapy.
In the present study, we describe tissue oxygen deficits in the perioperative period of an initial unselected series of 253 high-risk surgical patients and relate these to the subsequent development of organ failure and the systemic disorders, sepsis and disseminated intravascular coagulation (DIG). Jhe first aim of this study was to describe the temporal sequence of an estimated oxygen debt to organ failures and outcome.

August 1, 2013 Oxygen
Tags: anesthesia cardiac output organ failure oxygen