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- Modulation of the Onset of Postnatal Development of H+-ATPase: DISCUSSION(4)

We have shown previously that some other morphological effects on the reproductive tract that were observed after neonatal DES administration, such as rete testis distension, loss of aquaporin-1 expression in the efferent ducts, and malformation of the epididymis/vas deferens, were not altered after GnRHa administration, suggesting an estrogenic action of DES in addition to androgen suppression. In addition, previous reports have suggested that estrogens might be involved in the maturation of some epididymal cell types that express H+-ATPase.

Epididymal epithelial cells are structurally undifferentiated in all regions of the epididymis at Postnatal Day 21, and some H+-ATPase expressing cell types (i.e., caput and corpus epididymal clear cells) are not fully differentiated until Day 49 despite being exposed to high testosterone levels, which is consistent with a role for other factors in their maturation. Given that the postnatal epididymis contains receptors for estrogen receptor p (ERp), and that the major circulating steroid during postnatal development is 3a-diol, a putative ligand for ERp, an argument can be proposed in favor of a role for estrogens in the development of H+ATPase-rich cells.

November 26, 2013 Cell
Tags: epididymis estradiol male reproductive tract steroid hormones testosterone