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- Late Gestational Exposure to the Fungicide Prochloraz: RESULTS(4)

 RESULTS(4)

On PCD 25 male offspring from dams treated with PZ 125 or 250 mg/kg-BW per day had shorter anogenital distances compared with male controls (P = 0.006 and 0.0004, respectively), whereas female offspring in these two groups had larger anogenital distances compared with offspring of controls (P = 0.0369 and 0.0002, respectively). When anogenital distance was analyzed with body weight as the co-variate, no treatment effects on anogenital distance were significant in the males, but females in the 250 mg/kg-BW per day group had longer anogenital distances compared with those of other groups (Fig. 4).

Postimplantation loss on PCD 25 was greater in the 250 mg/kg-BW per day group (P < 0.0001). Neonatal pup loss (pup loss between PCD 25 and PCD 35) was also increased in the 250 mg/kg-BW per day group (P < 0.0081). The percentage of offspring (as a proportion of the number of fetal implants) that survived to weaning was reduced in a dose-related manner by PZ treatment (Table 2). Dams dosed with 125 or 250 mg/kg-BW per day weaned fewer pups than controls (P < 0.0348 and P < 0.0001, respectively).
Fig3Late Gestational Exposure to the-6
FIG. 3. Relationship of pup body weight at 3 days of age (PCD 25) to maternal dose. Error bars = SEM. Letters above bars show statistical groupings (P < 0.05) within the graph. Upper case letters refer to males, lower case letters refer to females. Groups sharing the same letter (e.g., A and AB) were not statistically different. Groups that do not share a letter (e.g., d and e) differed statistically (P < 0.05).

Fig4Late Gestational Exposure to the-7
FIG. 4. Relationship of anogenital distances at 3 days of age (PCD 25) to maternal dose. The data displayed on the left are adjusted anogenital distance values obtained when body weight was analyzed as a covariate, whereas the data on the right are unadjusted anogenital distance values. Error bars = SEM. Letters above bars show statistical groupings (P < 0.05) within the graph. Upper case letters refer to males, lower case letters refer to females. Groups sharing the same letter (e.g., A and AB) were not statistically different. Groups that do not share a letter (e.g., d and e) differed statistically.

April 1, 2014 Parturition
Tags: antiandrogen environment fungicide hypospadias male reproductive tract