Differential Regulation of Colony Stimulating Factor: DISCUSSION(5)


More recently, we have shown that IL1B induces an array of chemokines that promote monocyte/macrophage chemotaxis. Thus, TNF and IL1B may induce multiple macrophage-monocyte/macro-phage-recruiting chemokines that overcome the inhibitory effects of constitutively expressed MIF.

The effects of TNF and IL1B on CSF1 levels shown in the current study delineate a novel mechanism by which inflammatory cytokines can affect pregnancy.